SEROTYPE SPECTRUM AND EFFECTIVENESS OF VACCINE PROPHYLAXIS AGAINST S.PNEUMONIAE IN CHILDREN

In order to assess the effect of vaccination against Streptococcus pneumoniae on the serotype spectrum of pneumococcus, we conducted a bacteriological study of nasopharyngeal mucus of 247 healthy children attending kindergarten. In 35.6% (20) of practically healthy children, S. pneumoniae was isolated and serotyping of the isolated samples was carried out. In order to assess the effect of vaccination against Streptococcus pneumoniae on the serotype spectrum of pneumococcus, we conducted a bacteriological study of nasopharyngeal mucus of 247 healthy children attending kindergarten. In 35.6% (20) of practically healthy children, S. pneumoniae was isolated and serotyping of the isolated samples was carried out. The most common pneumococcal serotypes were 15A/F, 6 A/B, 9 A/V and 9 F, followed by 5 and 7 A in frequency /F, 23F serotypes. A study of specific antibodies to pneumococcus in vaccinated children showed a high level of immune response. Thus, it was found that vaccination with commercial pneumococcal vaccines protects the majority of vaccinated children. To assess the effectiveness of vaccination, it is necessary to study the circulation of serotypes in children after vaccination.