Published 2024 | Version v2
Dataset Open

High-throughput sequencing of Trastuzumab CDRH3 variant yeast display library

Authors/Creators

  • 1. ROR icon University of Oslo

Contributors

Researcher:

  • 1. ROR icon University of Oxford

Description

High-throughput sequencing dataset for Trastuzumab CDRH3 variant library.

Each library sample is created from flow cytometry-sorted yeast cells displaying variant Trastuzumab on the cell surface and categorized based on binding affinity with HER2:

  1. Sample 1: Tz variants strong binders
  2. Sample 2: Tz variants intermediate binders
  3. Sample 3: Tz variants weak binders

All processed data and weights from 'Baselining the Buzz. Trastuzumab-HER2 Affinity, and Beyond!' can be found in data.zip

Files

data.zip

Files (28.5 GB)

Name Size Download all
md5:f4404263fb087c69286a4ba219767034
4.3 GB Download
md5:9aeb009f5538e573dfd888447def84a9
4.0 GB Download
md5:6d002f6d5fe1087ee5b609782c90482b
4.2 GB Download
md5:cfa5718726536a8bdc8dcda0a8f010c9
4.1 GB Download
md5:d8d3c2eb6a16fe7ed0cd051be8e0717e
5.0 GB Download
md5:bf6a0f68ff91147ed6d3968d5b4a73df
4.2 GB Download
md5:3d5a61767dd5c3084ed015edb9b23cd7
2.5 GB Preview Download

Additional details

Software

Repository URL
https://github.com/oxpig/Tz_her2_affinity_and_beyond
Programming language
Python