Development Of Spanlastics: Nanovesicular Drug Delivery Of Oxiconazole Nitrate

Oxiconazole nitrate is used to treat fungal infections. It has a restrictive pharmaceutical role because of its poor aqueous solubility, which reduces the bioavailability of the drug. The present investigation was carried out to formulate and evaluate the Oxiconazole nitrate loaded spanlastic. Spanlastic was prepared by Ethanol injection method using Span 60 and Tween 80 as non-ionic surfactant and edge activator. The formulation was evaluated for various parameters like, particle size, transmittance, entrapment efficiency, surface morphology, surface charge and in vitro release studies. Out of eight formulations, F8 having minimum particle size of 452.56nm, transmittance of 79.23±0.23%, higher entrapment efficiency of 94.67±0.89% and dissolution of 82.74±1.34%. The vesicles were found to be spherical and tiny in size.  The surface charge of spanlastic was -5.74 mV. Thus it can be concluded that the developed Spanlastic formulation would be a promising delivery system with improved efficacy, controlled release and patient compliance.