THERAPEUTIC POTENTIAL OF NANOPARTICLES CONJUGATED WITH DRUG IN RELIEVING COLON RELATED DISORDERS

Globally, the prevalence of illnesses associated to the colon is increasing, with notable regional and national differences in disease patterns and levels. Drug administration can occur in the colon both locally and systemically. Topical therapy of inflammatory bowel disease is made possible by local delivery. On the other hand, if the medications are able to target the colon directly, the systemic adverse effects can be minimized and the treatment become more successful. Among the many benefits of nanoparticles is their larger volume/surface ratio, which increases the drug's contact area at the same dose and improves delivery efficiency. This may lessen the toxicity and adverse effects of drugs. Additionally, nanoparticles' easily modifiable surface enables the creation of sustained release mechanisms. By utilizing the physicochemical alterations that many colonic disorders cause, such as an increase in the infiltration of immune cells that are amenable to targeting in the colon, new developments have improved colon targeting nanosystems. This page provides an overview of diseases connected to the colon, colon-specific drug delivery strategies, an overview of nanoparticles, and a list of previously developed nanoparticulate drug delivery methods for the treatment of colon problems. Keywords: Colon, nanoparticles, formulation, characterization, nanotechnology