Published February 14, 2024 | Version v2
Poster Open

Multiscale imaging of the immune cell therapy biodistribution

Authors/Creators

  • 1. Cenya Imaging Bv
  • 2. ROR icon Wageningen University & Research
  • 3. Cenya Imaging Bv.

Description

Optimising therapeutic cell treatment is a challenge, especially with combination therapies and patient variability. The ability to study cell migration in a quantitative and non-invasive manner in vivo, of endogenous cancer-fighting immune cells (ICs) and administered therapeutic cells is essential for biomarker-driven and personalised clinical trials. Cenya BEACONs allow for multimodal, quantitative imaging of cell populations with quantitative 19F MRI, fluorescence, ultrasound, photoacoustics, PET and SPECT. Cenya’s GMP grade BEACONs consist of a PLGA shell and a PFCE multicore structure with Gd incorporated into the shell and can easily be used for a wide variety of therapeutic cells. The BEACONs are able to track cells over the course of multiple weeks and are cleared rapidly from dead cells.

https://www.cenyaimaging.com/science 

 

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Additional details

Funding

European Commission
Phoenix - Pharmaceutical Open Innovation Test Bed for Enabling Nano-pharmaceutical Innovative Products 953110

References

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