Systematic dissection of tumor-normal single-cell ecosystems across a thousand tumors of 30 cancer types

This is the collection of codes and datasets described in the paper "Systematic dissection of tumor-normal single-cell ecosystems across a thousand tumors of 30 cancer types"

This repository contains:

• Analyzed NMF, scRNA-seq, and Spatial matrix in h5ad format
• Analysis codes used for data analysis
• Documentation providing information on the analyzed datasets of both single-cell and spatial transcriptomes

The descriptions for each item are as follows:

• Raw post-QC normalized scRNA-seq matrix files for each dataset: 'atlas_dataset.tar'
  • Raw count matrices can be downloaded from the accession links in the 'scRNA-seq dataset Documentation’ file.
• Spatial matrix files for each dataset: 'spatial_dataset.tar'
• NMF module matrix files for each cell type: 'NMF_h5ad.tar'
• Analysis codes: 'analysis_codes.tar' and 'scjp.tar'