Published February 12, 2024 | Version v1
Dataset Open

Data from: Cryptic diversity of cellulose-degrading gut bacteria in industrialized humans

  • 1. Ben-Gurion University of the Negev
  • 2. Heinrich Heine University Düsseldorf
  • 3. Weizmann Institute of Science
  • 4. Newcastle University
  • 5. United States Department of Agriculture

Description

Humans, like all mammals, depend on the gut microbiome for digestion of cellulose, the main component of plant fiber, but evidence for cellulose fermentation in the human gut is scarce. We have identified ruminococcal species in the gut microbiota of human populations that assemble functional multi-enzymatic cellulosome systems capable of degrading plant cell wall polysaccharides. One of these species, which is strongly associated with humans, likely originated in the ruminant gut and was subsequently transferred to the human gut potentially during domestication, where it underwent diversification and diet-related adaptation through the acquisition of genes from other gut microbes. Collectively, these species are abundant and widespread among ancient humans, hunter-gatherers, and rural populations, but are extremely rare in populations from industrialized societies, suggesting potential disappearance in response to the westernized lifestyle.

Notes

Funding provided by: H2020 European Research Council
Award Number: ERC 866530

Funding provided by: H2020 European Research Council
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100010663
Award Number: 101018894

Funding provided by: FP7 Cooperation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100019767
Award Number: DIP 2476/2

Funding provided by: Israel Science Foundation
Crossref Funder Registry ID: https://ror.org/04sazxf24
Award Number: ISF 1947/19

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