miRNAs Expression Profiling, An Exploratory Method for Revealing First-Hand Biomarkers to Predict Disease Progression

Molecular techniques has proven to be a powerful tool to identify reliable predictors of treatment response or disease progression detection and early prediction. Different body cell possess various host expression profiles, and has its own specific indicators to identify different diseases/infection class. Analyzing microRNAs (miRNAs) as a promising host gene plays a critical roles in host interactions with various invaders, including their pathogenesis and host resistance through regulation of post-transcriptional translation or gene expression of related miRNAs, thus acting as a potential biomarkers of infectious diseases. Circulating miRNAs have great potential to facilitate the diagnosis of virus infection, although the discrepancy between the expression levels of intracellular and extracellular miRNAs, that has been observed in certain situations. Circulating miRNAs were found to be extremely stable and protected from RNAse mediated degradation within the body fluids, therefore have emerged as candidate biomarkers for several illnesses.