An Overview of Commonly Used Rodent Models for Studying PD-Related Olfactory Deficits

Olfactory dysfunction is a common issue in Parkinson’s disease (PD), affecting 70-95% of patients. Symptoms include impairments in odor detection, identification, and discrimination. Interestingly, olfactory dysfunction can present years before motor symptoms, and individuals who have hyposmia and a relative with PD are at greater risk for developing the disease. Herein you will find a list of models that display olfactory deficits from the Preclinical Tools and Models Team at The Michael J. Fox Foundation for Parkinson's Research (MJFF). Please note, this is not comprehensive.