An Overview of Commonly Used Rodent Models for Studying PD-Related Mitochondrial Dysfunction

Mitochondrial function is a pathway of great interest for Parkinson’s disease (PD) research and therapeutic development given the dysfunction that has been observed in idiopathic patients, patients with mutations in parkin/PINK1 genes, and mechanism of action for known environment toxins linked to PD. Mitochondrial dysfunction is observed in many PD models. In this overview document from the Preclinical Tools and Models Team at The Michael J. Fox Foundation for Parkinson's Research (MJFF), you will find a summary of models that use mitochondrial dysfunction to drive pathology. Please note, this list is not comprehensive.