An Overview of Commonly Used Rodent Models for Studying LRRK2

The mutations in the LRRK2 gene which increase the LRRK2 kinase activity are a common genetic form of Parkinson’s disease (PD). The most common mutation is the G2019S mutation which increases kinase activity ~1.5 fold. The R1441C/G mutation increases kinase activity ~4-fold. There are a number of models available to study LRRK2-related mutations/function. In the attached summary from the Preclinical Tools and Models Team at The Michael J. Fox Foundation for Parkinson's Research (MJFF), you will find a list of those that are commonly used. Please note, this list is by no means comprehensive -- others are available that may suit your needs.