An Overview of Commonly Used Rodent Models for Studying Alpha-Synuclein

As one of the hallmarks of Parkinson’s disease, alpha-synuclein (aSyn) pathology is a highly desired readout in model systems. There are many in vivo models available that use aSyn mutations, overexpression, or misfolding to trigger pathology, degeneration, and behavioral readouts. In this overview document from the Preclinical Tools and Models Team at The Michael J. Fox Foundation for Parkinson's Research, you will find a list of commonly used aSyn-driven models of Parkinson’s disease. Please note, this list is by no means comprehensive--others are available that may suit your needs.