Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation
Authors/Creators
- Boeren, Marlies1
- de Vrij, Nick1
- Ha, My1
- Souquette, Aisha2
- Valkiers, Sebastiaan1
- Gielis, Sofie1
- Schippers, Jolien1
- Bartholomeus, Esther1
- Van den Bergh, Johan1
- Michels, Nele1
- Aerts, Olivier1
- Leysen, Julie1
- Bervoets, An1
- Lambert, Julien1
- Leuridan, Elke1
- Wens, Johan1
- Peeters, Karin1
- Emonds, Marie-Paule3
- Elias, George1
- Vandamme, Niels4
- Jansens, Hilde5
- Adriaensen, Wim6
- Suls, Arvid1
- Vanhee, Stijn1
- Hens, Niel1
- Smits, Evelien1
- Van Damme, Pierre1
- Thomas, Paul G.2
- Beutels, Philippe1
- Ponsaerts, Peter1
- Van Tendeloo, Viggo1
- Delputte, Peter1
- Laukens, Kris1
- Meysman, Pieter1
- Ogunjimi, Benson1
- 1. Universiteit Antwerpen
- 2. St. Jude Children's Research Hospital
- 3. Rode Kruis-Vlaanderen
- 4. Ghent University
- 5. Antwerp University Hospital
- 6. ITG
Description
Data for "Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation"
Data directories
- bulk-1week
Contains processed bulk TCR sequencing data from cohort 1.
- longitudinal
Contains processed bulk TCR sequencing data from cohort 2.
Note that this is the same dataset as reported in the following reference (it is included again in this repository for completeness):
B. Ogunjimi, J. Van den Bergh, P. Meysman, S. Heynderickx, K. Bergs, H. Jansens, E. Leuridan, A. Vorsters, H. Goossens, K. Laukens, N. Cools, V. Van Tendeloo, N. Hens, P. Van Damme, E. Smits, P. Beutels, Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox. Sci Rep 7, 1077 (2017).
- single-cell
Contains processed single cell data from cohort 1.
- stim
Contains TCR data from stimulation experiments.
Script directories
- src
Contains various scripts used to generate the results and figures in the manuscript.
Result directories
- results
Contains the inbetween files for many of the analyses.
Contains the Seurat object for the single cell analysis reported in the paper.
Also used as output directory for the scripts listed in src.
- tcrex_results
Full results from using the aforementioned data sets with the TCRex tool:
https://tcrex.biodatamining.be/
Files
boeren-et-al.zip
Files
(451.0 MB)
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