IRCCS Humanitas Research Hospital & Humanitas University
Published October 25, 2023 | Version v1
Dataset Restricted

Dataset related to article "The impact of biologic therapy for moderate-to-severe psoriasis on the immune responses to SARS-CoV-2 infection and vaccination"

Authors/Creators

  • 1. ROR icon IRCCS Humanitas Research Hospital
  • 2. ROR icon Humanitas University
  • 3. Humanitas Research Hospital
  • 4. University of Verona

Description

Dataset related to article "The impact of biologic therapy for moderate-to-severe psoriasis on the immune responses to SARS-CoV-2 infection and vaccination"

In our study we explored the impact of biologics and conventional therapies on humoral and T-cellular responses to SARS-CoV-2 infection and vaccine, comparing the results with the healthy donors’ immune responses. The main findings of our study are that while biologic therapy for moderate-to-severe psoriasis with anti-IL23 and IL-17 has no significant effect on the humoral and T-cell mediated immune response; in contrast, conventional therapies and TNF-a blockade reduce the production of specific antibodies. Moreover, our results suggest that treatment with anti-IL-23 can enhance anti-covid responses induced by the vaccine since we found higher antibody levels in vaccinated patients treated with IL-23 inhibitors with an effect on follicular T helper cells.

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Additional details

Related works

Is supplemented by
Publication: 10.1093/bjd/ljad242 (DOI)
Publication: 37463513 (PMID)

Funding

Fondazione Cariplo
Impact of COVID-19 infection on patients affected by inflammatory skin disease on immune-suppressive therapies COVISKIN 2020-1363