UK Biobank MGUS GWAS Results

The UK Biobank is a large-scale biomedical database and research resource, containing genetic and health information from half a million individuals aged 40 to 69 years in the United Kingdom. The genotyping methods and quality control steps previously reported (PMID: 30305743).  The MGUS cases were defined by using cancer registry data (Data-Field 40011 and Data-Field 40006) by using ICD-10 code D47.2 and ICD-O-3 code  9765. The control group was created by removing participants who had any cancer-related record in either another cancer registry, hospital record, or self-reported history of cancer. From the whole cohort, participants were removed if they reported non-white British ethnic background, sex chromosome aneuploidy, genetic relatedness exclusions, recommended genomic analysis exclusions, genetic and reported sex mismatch. After exclusion steps, a total of 107 MGUS cases and 277496 controls were used for GWAS analysis. The association models in both steps also included the following covariates: age (cases: age at diagnosis, controls: age at recruitment), sex, genotyping array, and the first 10 genetic principal components (PCs).

Column Names in the summary statistics:

CHROM: Chromosome

GENPOS: HRCH_37 position

ID:rsid

ALLELE0: Non-effect Allel

ALLELE1: Effect Allel

A1FREQ: Freq of effect allel

A1FREQ_CASES

A1FREQ_CONTROLS

INFO

N

N_CASES

N_CONTROLS

TEST

BETA

SE

CHISQ

LOG10P

EXTRA

SNP: SNP names in Chr:Pos:A0:A1

P