UPDATE ON THE DIAGNOSIS AND MANAGEMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS
Description
Background: systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organ systems, characterized by immune dysregulation and the production of autoantibodies. Pathogenesis involves aberrant activation of programmed cell death (PCD) signaling and accelerated cell death, leading to self-antigens release. SLE manifests with diverse symptoms, ranging from musculoskeletal and gastrointestinal symptoms to neuropsychiatric and cardiovascular complications.
Objective: The present study aims to review the update on the diagnosis and management of systemic lupus erythematosus
Methods: Comprehensive research of the diagnosis and management of SLE. PUBMED and Google scholar search engines were the database used for the search process, and articles were collected from 2013 to 2023. The term used in the search were: Systemic lupus erythematosus (SLE) – manifestation – Diagnostic criteria – treatment.
Conclusion: Accurate diagnosis relies on established criteria like ACR-1997, SLICC-2012, and EULAR/ACR-2019, incorporating clinical and immunological features. Various diagnostic methods, such as immunoassays and multi-omics analysis, contribute to precise diagnosis, with ongoing evaluation of criteria in juvenile SLE. SLE management involves a multidisciplinary approach, combining conventional therapies, targeted biological agents, and adjuvant treatments. The focus remains on improving treatment response, enhancing quality of life, and minimizing side effects. Ongoing research endeavors seek to deepen our understanding of SLE and develop novel therapeutic strategies for this challenging autoimmune disorder.
Keywords: Systemic lupus erythematosus (SLE) – manifestation – Diagnostic criteria – treatment.