IN-VITRO EVALUATION OF QUALITY CONTROL PARAMETERS OF PIROXICAM TABLETS MARKETED IN INDIA

Analgesic and antipyretic, piroxicam is typically used to treat osteoarthritis and rheumatoid arthritis by lowering temperature and relieving pain. Currently, every pharmaceutical company uses a different manufacturing process and technology to make different types of piroxicam pills. The study's objective is to assess and compare many kinds of 20 mg piroxicam tablets. Fiveb distinct brands of 20 mg piroxicam tablets were chosen for this study from nearby marketplaces in India and examine their quality control measures, such as disintegration and dissolution tests, hardness, friability, and weight variation.The test results for all four brands of piroxicam l tablets were found to be within acceptable bounds; the weight variation was found to be within ±5% of the average weight, and the friability was found to be less than 1%. The disintegration time for each brand of piroxicam tablet was found to be within three minutes, and the percentage release of all brands of piroxicam tablets was found to be not less than 85%. IP specification limit in less than half an hour. Thus, we concluded that, with the exception of price, all piroxicam tablets from various manufacturers are safe and effective to use.

Key Words:piroxicam, analgesic , antipyretic, comparative study.