EVALUATION OF IBUPROFEN - IN SELF EMULSIFYING DRUG DELIVERY SYSTEM

SEDDS (Self Emulsifying Drug Delivery System) is an isotropic mixture of oil, surfactant, solvent and co -solvent/surfactants that can be used to design formulations for oral administration of highly lipophilic drugs. SEDDS can be administered orally in soft/hard gelatin capsules. SEDDS form fine (or micro) emulsions in GIT with mild gastric agitation. Many parameters such as surfactant concentrations, oil / surfactant ratio, emulsion polarity and droplet size/charge play an important role in oral drug absorption from SEDDS. This formulation improves bioavailability by increasing drug solubility and minimizes gastric irritation due to the hydrophobic nature of nearly 40% of new drug compounds.This formulation can be used to enhance oral absorption of drugs that are not soluble orally, such as Ibuprofen. The purpose of this study is to formulate SEDDS for Ibuprofen and to evaluate its anti inflammatory properties in vitro and in vivo. The following evaluations were performed on the SEDDS formulations: Visual Isotropicity, Emulsification Time, Drug Content, In vitro Drug Release, Post Dilution Drug Precipitation, and In vivo Anti Inflammation Testing. All batches passed the Visual Isotropic test, Emulsification time was less than 1 minute, and the drug release was rapid. Infinite Aqueous Dilution showed no Phase separation and no phase separation. In vivo anti inflammatory studies showed significantly higher anti inflammatory activity (p <0.05). Ibuprofen  powder