Published February 20, 2024 | Version 0.0.1
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European LD files for GhostKnockoffGWAS

Description

This contains pre-processed LD files (Sigma matrix, S matrix, ...etc) computed on the EUR cohort of Pan-UKB LD data. It is intended to be used as an input to the GhostKnockoffGWAS pipeline.

  • We restricted our attention to the EUR panel 
  • We filtered the original HailBlockMatrix LD panel to genotypes that are typed (i.e. imputed SNPs were removed)
  • Coordinates in both hg19 and hg38 are available. Conversion from hg19 to hg38 were achieved by the R package liftOver. 
  • Downloading and processing of the original HailBlockMatrix formatted data is accomplished by the EasyLD.jl software: https://biona001.github.io/EasyLD.jl
  • Knockoff optimization were carried out by the Knockoffs.jl julia package: https://github.com/biona001/Knockoffs.jl
  • The result (i.e. files available in this site) is saved in .csv and .h5 formatted files for easier access, which is directly readable by GhostKnockoffGWAS

 

Files

EUR.zip

Files (7.5 GB)

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md5:803efe4fe269ed64719356e91bd6f457
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Additional details

Dates

Created
2024-02