EVALUATION OF ANTI-EPILEPTIC ACTIVITY OF CHLOROFORM EXTRACT OF LEAVES OF BARRINGTONIA RACEMOSA IN MICE

Objective: The present study was aimed to evaluate antiepileptic activity of chloroform extract of leaves of Barringtonia racemosa (CBR) in mice. Methods: The antiepileptic activity of CBR was evaluated in mice at 30, 100, and 300 mg/Kg, p.o. by the convulsions induced by maximum electroshock (MES), Pentylenetetrazole (PTZ) and Isoniazid (INH) methods. Statistical analysis was carried out by one-way analysis of variance (ANOVA) followed by Dunnett’s t test. Results: In MES method, CBR (30, 100, and 300 mg/Kg) inhibited convulsions significantly potent than Diazepam. In PTZ method, CBR inhibited convulsions potent than Phenobarbitone sodium (PS). In INH method, CBR delayed the onset of convulsions less potent than Diazepam. Conclusion: In Present investigation, CBR showed significant dose dependent antiepileptic effect potent than Diazepam and PS. Keywords: Epilepsy, Barringtonia racemosa, Pentylenetetrazole, Isoniazid.