Agent-Based Model of Muscle Regeneration with Microvascular Remodeling

This agent-based model uses the Cellular Potts framework to simulate the dynamic microenvironment of a cross-section of murine skeletal muscle tissue. It simulates the spatial behaviors of muscle fibers, satellite stem cells (SSC), fibroblasts, neutrophils, macrophages, microvessels, and lymphatic vessels, as well as their interactions with each other and the microenvironment. The model was used to perturb altered cytokine dynamics to analyze the impact on cell behaviors and recovery outcomes.