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Published December 18, 2023 | Version v1
Model Open

Agent-Based Model of Muscle Regeneration with Microvascular Remodeling

  • 1. ROR icon University of Virginia
  • 2. Purdue University

Description

This agent-based model uses the Cellular Potts framework to simulate the dynamic microenvironment of a cross-section of murine skeletal muscle tissue. It simulates the spatial behaviors of muscle fibers, satellite stem cells (SSC), fibroblasts, neutrophils, macrophages, microvessels, and lymphatic vessels, as well as their interactions with each other and the microenvironment. The model was used to perturb altered cytokine dynamics to analyze the impact on cell behaviors and recovery outcomes.

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Additional details

Related works

Is published in
Journal: 10.7554/eLife.91924.1 (DOI)

Funding

R21 R21AR080415
National Institute of Health
NSF GRFP 1842490
National Science Foundation

Dates

Available
2024-01-09