Published December 15, 2023
| Version first verion
Dataset
Open
Raw data for "Development and characterization of a non-human primate model of disseminated synucleinopathy"
Creators
- 1. CNS Gene Therapy Program, Center for Appplied Medical Research (CIMA), Univiersity of Navarra, Pamplona, Spain
- 2. CNS Gene Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra
- 3. CNS Gene Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain
Description
In this study, the performance and biodistribution of the retrogradely-spreading AAV9-SynA53T vector was evaluated in the NHP brain. Conducted intraparenchymal deliveries of viral suspensions in the left putamen gave rise to a disseminated synucleinopathy in a circuit-specific basis.
Files
Fig 1A'.tif
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Additional details
Additional titles
- Alternative title (English)
- Figures for "Development and characterization of a non-human primate model of disseminated synucleinopathy"
Funding
- Aligning Science Across Parkinson's
- Activity and connectivity drive neuronal vulnerability and disease progression in Parkinson's disease ASAP-020505
- Ministerio de Ciencia, Innovación y Universidades
- Use of adeno-associated viral vectors for the design and validation of pathophysiological models of Parkinson's disease in non-human primates PID2020-120308RB
Dates
- Submitted
-
2023-12-15