Single-unit auditory nerve fibre responses of young-adult and aging gerbils
Description
This dataset was collected to study the functional consequences of age-related hearing loss for the auditory nerve, which carries acoustic information from the periphery to the central auditory system. Using high-impedance glass electrodes, raw voltage traces and spike times were recorded from more than one thousand single fibres of the auditory nerve of young-adult, middle-aged, and old Mongolian gerbils raised in a quiet environment. The dataset contains not only responses to simple acoustic stimuli to characterize the fibres, but also to more complex stimuli, such as speech logatomes in background noise and Schroeder-phase stimuli. A software toolbox is provided to search through the dataset, to plot various analysed outcomes, and to give insight into the analyses. This dataset may serve as a valuable resource to test further hypotheses about age-related hearing loss. Additionally, it can aid in optimizing available computational models of the auditory system, which can contribute to, or eventually even fully replace, animal experiments.
Notes
Funding provided by: Deutsche Forschungsgemeinschaft
Crossref Funder Registry ID: https://ror.org/018mejw64
Award Number: 390895286
Funding provided by: Deutsche Forschungsgemeinschaft
Crossref Funder Registry ID: https://ror.org/018mejw64
Award Number: PP 1608
Methods
The dataset presented here contains the raw waveforms and spike times from single auditory nerve fibres of young-adult, middle-aged, and old gerbils, while presenting a variety of acoustic stimuli to assess the functioning of the single fibres. Gerbils were anesthetized with ketamine/xylazine injections and auditory brainstem responses (a type of compound response) were recorded to derive a measure of their general hearing sensitivity. The auditory nerve was approached dorsally through the cerebellum and a sharp, high-impedance glass electrode was slowly moved through the nerve. Single-unit recordings were made for as long as the surgical preparation was stable. Afterwards, spikes in the data were identified, data files were organized into folders of one single unit, data were analysed to characterize the fibre, and a set of criteria was used to ensure the single unit derived from the auditory nerve bundle. Methods are described in detail in the accompanying manuscript.
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Additional details
Related works
- Is cited by
- 10.3389/fnins.2023.1238941 (DOI)
- 10.1523/JNEUROSCI.2784-18.2019 (DOI)
- 10.1016/j.neurobiolaging.2021.08.019 (DOI)
- 10.1523/ENEURO.0474-21.2021 (DOI)
- Is source of
- 10.5061/dryad.qv9s4mwn4 (DOI)