MOLECULAR DYNAMICS SIMULATION-BASED PHYTOCHEMICAL SCREENING OF BLINDING TREE (EXOECARIA AGALLOCHA) LEAF EXTRACT AGAINST CERVICAL CANCER BY TARGETING SIHA CELL LINE

The anticancer fruit of the blinding tree, Exoecaria agallocha, is a member of the Euphorbiaceae family and is commonly found in India. It is used to treat paralysis, rheumatism, leprosy, ulcers, and epilepsy. When treating cervical cancer, exoecaria agallocha can be utilised as a comprehensive treatment. The precise chemical mechanism underlying blindness trees' anticancer action is still unknown. The (SiHa HPV 16+) cell line's crystal structure was obtained from the Protein Data Bank. When the active ingredients of exoecaria agallocha (bergenin, rutin, and afzelin) were molecularly docked with cervical cancer protein, the proliferation of cervical cancer cells was significantly reduced and altered. Exoecaria agallocha has the ability to prevent cervical cancer, as demonstrated by this experiment. The study's conclusions provide important new information.

Keywords: Exoecaria agallocha, SiHa cell line, Bergenin, Rutin, Afzelin.