HERBOSOME A NOVEL APPROACH TOWARDS DRUG DELIVERY

When it comes to improving human health, herbal therapies are always more beneficial than alternative allopathic medications. In this context, novel drug delivery methods will boost the bioavailability of phyto-pharmaceuticals, which are plant extracts complexed with phospholipid and a mixture of aprotic solvents. Compared to a straightforward herbal extract, phyto-phospholipid has a more advanced and accessible biological pathway that allows it to pass through membranes and enter the bloodstream. Using phyto-phospholipid, herbosome technology is one of the unique approaches to boost the bioavailability of phyto-pharmaceuticals. Formulation can be done in a lot of different ways, some of which are even patented. Silymarin, Ginkgo, Ginseng, Grape Seed, and Curcumin are among the medications that are still undergoing clinical testing and some that are available for purchase. Herbosomal formulations hold greater significance in the administration of targeted medications due to their enhanced bioavailability compared to normal formulations. Herbosomes are characterized in vitro by the examination of their microscopical characteristics, entrapment efficiency, percentage yield, zeta potential, particle size, surface texture analysis, and drug release profile. TEM, PCS, DSC, DLS, XRD, NMR, and FT-IR spectroscopy are a few of the instrumental techniques used. An effective barrier is provided by the diffusion-mediated drug release from the vesicle-structured herbosome, which also enables the design of topical and oral drug delivery systems for systemic impact. The results of previous studies and our personal discoveries about phyto-phospholipid complexes with additional components are highlighted in the current work.

Keywords: Herbosomes, Phospholipid, Bioavailability, Phytomedicine, Bio-membrane penetration.