Python code to simulate mouse, monkey and human brains

This archive contains the python codes to run the TVB-AdEx model of mouse, monkey and human brains.  The models run in The Virtual Brain simulator, where AdEx mean-fields were implemented.  This model reproduces two brain states, asynchronous activity similar to wakefulness, and slow-wave activiy similar to sleep and anesthesia.

The human model is described in the following papers:

Goldman, J.S., Kusch, L., Yalcinkaya, B.H., Depannemaecker, D., Nghiem, T-A., Jirsa, V. and Destexhe, A.  Brain-scale emergence of slow-wave synchrony and highly responsive asynchronous states based on biologically realistic population models simulated in The Virtual Brain. bioRxiv (2020):  https://www.biorxiv.org/content/10.1101/2020.12.28.424574v1

Goldman, J.S., Kusch, L., Aquilue, D., Yalcinkaya, B.H., Depannemaecker, D., Ancourt, K., Nghiem, T-A., Jirsa, V. and
Destexhe, A.  A comprehensive neural simulation of slow-wave sleep and highly responsive wakefulness dynamics. Frontiers in Computational Neuroscience 16: 1058957, 2022.  DOI: https://doi.org/10.3389/fncom.2022.1058957

The three species (human, monkey, mouse) are described in:

Goldman, J., Sacha, M., Kusch, L. and Destexhe, A. Asynchronous and slow-wave oscillatory states in connectome-based models of mouse, monkey and human cerebral cortex. Biorxiv (2023): https://www.biorxiv.org/content/10.1101/2023.08.03.551869v1

See these papers for details.

The mouse and macaque brain models were built in a very similar way.

This work was financed by the Human Brain Project, under the direction of Alain Destexhe.