Antibody Characterization Report for Matrin-3 (2023)
Creators
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1.
Montreal Neurological Institute and Hospital
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2.
McGill University
Description
This report presents a guide to selecting high-quality commercial antibodies against Matrin-3 by immunoblot (Western blot), immunoprecipitation and immunofluorescence, using a knockout based validation approach. The research displayed in this study can be considered a subsequent study following the initial Matrin-3 report published to the YCharOS community in 2022 (10.5281/zenodo.5644346). In this study, only the recombinant antibodies were retested in all three applications, employing our revised standardized protocols.
This study was funded in part by Genome Québec's Genomics Integration Program, awarded to the research laboratory of Peter S. McPherson.It is part of the ALS-Reproducible Antibody Platform (ALS-RAP), established as a public-private partnership by three prominent ALS charities - the ALS Association (USA), the Motor Neurone Disease Association (UK), and the ALS Society of Canada.
Files
Matrin-3_MATR3_YCharOS report_2023_v2.pdf
Files
(2.3 MB)
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Additional details
Dates
- Submitted
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2023-11-09