PTMoreR: a motif-centric analysis enabling cross-species PTM mapping and comparative phosphoproteomics across mammals

Supplementary Table S2-S7 for PTMoreR

Table S2. The 115,179 and 42,997 phosphorylation sites (P-sites) for human and mouse phosphoproteomes obtained from two recent large-scale studies ^1,2. Two sheet names here are marked as “Human.identified” and “Mouse.identified” respectively.

Table S3. The information and organism identifies for the 129 mammalian species downloaded from UniProt (http://www.uniprot.org/) ³.

Table S4. The features and the detectability matrix of P-sites in the Human.identified phosphoproteome data across species. Column 1 to 3 are UniProt ID, residue, and P-site position, respectively. Column 4 to 17 are the annotated phosphoproteome features that used in the Figure 2C, Figure 4B, 4E, 4F, Supplementary Figure S4 and S7B-S7C. Column 18 to 146 are the detectability matrix, in which the values are 0 for those sites not mapped in corresponding species and 1 for those mapped. The window similarity scores are >= 8.

Table S5. The GO terms with the BH adjusted P value < 0.01 in one of Q1-Q5 segments and > 0.05 in the other four from the GO enrichment analysis based on corresponding phosphoproteins.

Table S6. The results with BH adjusted P value < 0.01 from the kinase enrichment analysis in each of Q1-Q5 segments.

Table S7. The phosphorylation expression data and statistical results from 10 common mammalian species (Euarchontoglires (i.e., Human, Rat, Rabbit, Monkey) and Laurasiatheria (i.e., Cow, Horse, Pig, Dog, Cat, Sheep)) ⁴.

References

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