Published April 1, 2024
| Version v1
Journal article
Open
Unveiling spatial complexity in solid tumor immune microenvironments through multiplexed imaging
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1.
University Children's Hospital Tübingen
- 2. DFG Cluster of Excellence 2180 iFIT
- 3. German Cancer Consortium (DKTK), partnerside Tübingen, a partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen
- 4. German Cancer Consortium (DKTK), partner site Tübingen, a partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen
Contributors
- 1. University Children's Hospital Tübingen
- 2. School of Business and Economics, Faculty of Economics and Social Sciences, University of Tübingen
- 3. Institute of Pathology and Neuropathology, University Hospital Tübingen and Comprehensive Cancer Center
- 4. Institute of Tissue Medicine and Pathology (ITMP), University of Bern
Description
This study provides a novel, comprehensive immunophenotyping antibody panel for multiplexed tissue imaging, encompassed by a validated analysis workflow. It serves as a blueprint for an ultra-deep spatial analysis of subtypes and cellular states of immune and tumor cells, allowing for precise and unprecedented deciphering of tumor (immune) microenvironments.
Files
Tonsil 1 - processed images.zip
Files
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Additional details
Related works
- Is metadata for
- Dataset: 10.3389/fimmu.2024.1383932 (DOI)
Software
- Programming language
- R , Python console