FORMULATION AND EVALUATION OF ITOPRIDE HYDROCHLORIDE CONTROLLED RELEASE TABLETS
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In the present work, an attempt has been made to developed Controlled release tablets of Felodipine by selecting different types of Na CMC, HPMC K 100 and Sodium alginate as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among the entire formulations 9 formulations showed maximum % drug release i.e., 98.68 % in 12 hours. Hence it is considered as optimized formulation F5 which contains HPMC K 100 (30mg). The optimized formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed Peppas release kinetics mechanism of drug release.
Keywords: Felodipine, Na CMC, HPMC K 100, Sodium alginate and Controlled release tablets.
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18.Naga Malleswhari- Manuscript- Ceutics.pdf
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