FORMULATION AND EVALUATION OF ITOPRIDE HYDROCHLORIDE CONTROLLED RELEASE TABLETS

The aim of the present study was to develop controlled release formulation of Itopride hydrochloride to maintain constant therapeutic levels of the drug for over 12 hrs.  HPMC K 15M, HEC 2M, HPC 2M were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. From the dissolution studies it was evident that the formulation (F7) showed better and desired drug release pattern i.e., 98.68 % in 12 hours. It contains the HPC 2M polymer. It followed Zero order release kinetics mechanism.

Keywords: Itopride hydrochloride, HPMC K 15M, HEC 2M, HPC 2M and Controlled release tablets.