EFFECT OF HYDROPHILIC POLYMERS ON INVITRO RELEASE RATE OF BUPROPION FLOATING TABLETS BY EMPLOYING EFFERVESCENT METHOD

Formulation and evaluation of floating tablets of Bupropion. In the present study the formulations were prepared by direct compression method using different proportions of Chitosan, Carbopol, Ethyl Cellulose as Swellable polymers. Sodium bicarbonate is used as buoyancy-imparting agent. The prepared formulations were evaluated for different parameters during its pre-compression and Post-compression stages. The release characteristics of the formulations were studied in in-vitro conditions. The in-vitro dissolution study of formulation F5 was 98.31 % within 12 h for good release and was fitted to kinetics of drug release for R2 value of Zero order release mechanism model is 0.982. As an extension of this work for formulation F5, bioavailability, pharmacokinetic, and in-vivo studies can be done in future to develop as suitable candidate for a novel drug delivery system.

Key words:  Bupropion, Chitosan, Carbopol, Ethyl Cellulose and Floating Tablets.