FORMULATION AND EVALUATION OF NIOSOMES OF KETOCONAZOLE

Formulation of niosome of ketoconazole was prepare by hand shaking method (thin film hydration technique) and then converting into gel by adding gelling agent Carbopol 934. Four formulations were prepared and characterized by different parameter like entrapment efficiency, drug content, morphology, pH, percentage yield, in- vitro release and stability studies. In study all formulations show good results but on the basis of drug content, percentage yield, in vitro release and stability studies F1 formulation found the best. Conclusion- Niosomes can be used for further formulation development like ointment creams or gel for topical use to treat fungal infections.

Keywords- Niosomes, Carbopol 934, In-vitro release, Percentage yield