Journal article Open Access

The role of the adipocyte hormone adiponectin in cardiovascular disease

Hug, Christopher; Lodish, Harvey F.

Adiponectin, a novel hormone made by fat tissue, regulates energy metabolism and endothelial activation. Serum levels of adiponectin are reduced in conditions that are associated with an increased risk of cardiovascular disease, such as diabetes and the metabolic syndrome. Adiponectin trimers assemble into higher-order oligomers, which have different signaling properties. Adiponectin trimers and a C-terminal globular domain activate AMP-activated protein kinase, whereas hexamer and high-molecular weight isoforms activate nuclear factor-kappa B signaling pathways. Exogenous adiponectin corrects metabolic defects that are associated with insulin resistance, and might protect the endothelium from the progression of cardiovascular disease. Receptors for adiponectin have been described and might provide future therapeutic targets for the treatment of cardiovascular disease.

Files (155.8 kB)
Name Size
article.pdf
md5:5ad3bc404367259f859af8b9aa33022a
155.8 kB Download
79
38
views
downloads
Views 79
Downloads 38
Data volume 5.9 MB
Unique views 79
Unique downloads 37

Share

Cite as