Journal article Open Access

STAT4: A Critical Regulator of Inflammation In Vivo

Kaplan, Mark H.

STAT4 is a central mediator in generating inflammation during protective immune responses and immune-mediated diseases. In the eight years since their first description, STAT4-deficient mice have defined the role of STAT4 in a variety of in vivo model systems. Despite the extensive study and use of these mice, the exact role of STAT4 in vivo is still unclear. In this review, I will focus on describing the phenotypes of STAT4-deficient immune responses to pathogens and in diseases. Comparing the effects of STAT4-deficiency among numerous model systems will further enhance the development of a systemic model of STAT4 function in vivo.

Files (198.8 kB)
Name Size
article.pdf
md5:4cce1c6563a051d089370b14bcc420e9
198.8 kB Download
62
61
views
downloads
Views 62
Downloads 61
Data volume 12.1 MB
Unique views 60
Unique downloads 60

Share

Cite as