STAT4: A Critical Regulator of Inflammation In Vivo

STAT4 is a central mediator in generating inflammation during protective immune responses and immune-mediated diseases. In the eight years since their first description, STAT4-deficient mice have defined the role of STAT4 in a variety of in vivo model systems. Despite the extensive study and use of these mice, the exact role of STAT4 in vivo is still unclear. In this review, I will focus on describing the phenotypes of STAT4-deficient immune responses to pathogens and in diseases. Comparing the effects of STAT4-deficiency among numerous model systems will further enhance the development of a systemic model of STAT4 function in vivo.