Published January 1, 2014
| Version v1
Journal article
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Structural insights into how 5-hydroxymethylation influences transcription factor binding.
Description
Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.