Published July 1, 2008
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Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus
Description
Three new polyketides, cyathuscavins A (1), B (2), and C (3) were isolated from the mycelium culture of
Cyathus stercoreus. The structures of the compounds were elucidated on the basis of NMR and mass spectroscopic
data. Antioxidant activities of the compounds were evaluated by the scavenging ability against
ABTS+, DPPH, and superoxide anion radicals. Cyathuscavins A–C showed significant antioxidant activity
comparable to those of reference antioxidants, BHA and Trolox. Cyathuscavins A–C protected supercoiled
plasmid DNA from Fe2+/H2O2-induced breakage.
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