Published September 1, 2013
| Version v1
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Atomic water channel controlling remarkable properties of a single brain microtubule: Correlating single protein to its supramolecular assembly
Description
Microtubule nanotubesarefoundineverylivingeukaryoticcells;theseareformedbyreversible
polymerizationofthetubulinprotein,andtheirhollow fibersare filledwithuniquelyarrangedwater
molecules.Herewemeasuresingletubulinmoleculeandsinglebrain-neuronextractedmicrotubule
nanowirewithandwithoutwaterchannelinsidetounraveltheiruniqueelectronicandopticalproperties
for the firsttime.Wedemonstratethattheenergylevelsofasingletubulinproteinandsinglemicrotubule
madeof40,000tubulindimersareidenticalunlikeconventionalmaterials.Moreover,thetransmittedac
powerandthetransient fluorescencedecay(singlephotoncount)areindependentofthemicrotubule
length.Evenmoreremarkableisthefactthatthemicrotubulenanowireismoreconductingthanasingle
proteinmoleculethatconstitutesthenanowire.Microtubule's vibrationalpeakscondensetoasinglemode
thatcontrolstheemergenceofsizeindependentelectronic/opticalproperties,andautomatednoise
alleviation,whichdisappearwhentheatomicwatercoreisreleasedfromtheinnercylinder.Wehave
carriedoutseveraltrickystate-of-the-artexperimentsandidentified theelectromagneticresonancepeaksof
singlemicrotubulereliably.Theresonantvibrationsestablishedthatthecondensationofenergylevelsand
periodicoscillationofuniqueenergyfringesonthemicrotubulesurface,emergeastheatomicwatercore
resonantlyintegratesallproteinsarounditsuchthatthenanotubeirrespectiveofitssizefunctionslikea
singleproteinmolecule.Thus,amonomolecularwaterchannelresidinginsidetheprotein-cylinderdisplays
an unprecedentedcontrolingoverningthetantalizingelectronicandopticalpropertiesofmicrotubule.
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