Antioxidant effects of Jasonia candicans and Jasonia montana extracts on rats blood sample

The principle goal of the present article is to investigate the potential role of the ethanolic extracts of aerial parts of Jasonia candicans and Jasonia montana in management of oxidative stress in male rats treated with aluminum chloride (AlCl₃). Supplementation of drinking water with 0.3 g/L of aluminum chloride (AlCl₃) in a dose of 0.3 g/L for 16 weeks induced oxidative stress with significant increase in serum creatinine level, alanine transferase (ALT), aspartate trasferase (AST) activity, malondialdehyde (MDA) and hepatic DNA fragmentation levels. However, oral administration of the ethanolic extract of Jasonia candicans or Jasonia montana at concentration of 150 mg/kg bw daily for 6 weeks showed significant decrease in serum creatinine and ALT activity associated with insignificant change in serum AST acivity, MDA or DNA fragmentation level in liver tissues compared to the negative control group.