Journal article Open Access

A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System

Dokoumetzidis, Aristides; Dokoumetzidis A., Macheras P.; Macheras, Panos

Dissolution research started to develop about 100 years ago as a field of physical chemistry and since then important progress has been made. However, explicit interest in drug related dissolution has grown only since the realisation that dissolution is an important factor of drug bioavailability in the 1950s. This review attempts to account the most important developments in the field, from a historical point of view. It is structured in a chronological order, from the theoretical foundations of dissolution, developed in the first half of the 20th century, and the development of a relationship between dissolution and bioavailability in the 1950s, going to the more recent developments in the framework of the Biopharmaceutics Classification System (BCS). Research on relevant fields of pharmaceutical technology, like sustained release formulations, where drug dissolution plays an important role, is reviewed. The review concludes with the modern trends on drug dissolution research and their regulatory implications.

Files (376.0 kB)
Name Size
article.pdf
md5:1d37a05d34bbfd438add19168e7f33d8
376.0 kB Download
44
44
views
downloads
Views 44
Downloads 44
Data volume 16.5 MB
Unique views 43
Unique downloads 43

Share

Cite as