PREPARATION AND IN-VITRO EVALUATION OF IMMEDIATE RELEASE TABLETS OF CHLORPROPAMIDE

The aim of the present study is to develop and evaluate the immediate release tablet of Chlorpropamide by direct compression method. The Superdisintegrant Primojel, Ac-Di-Sol and Polyplasdone XL10 were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F3 exhibit highest dissolution using Crospovidone showed faster drug release 98.01% over the period of 45min while disintegration time of the tablet was showed 25sec comparison to other formulations of Chlorpropamide.

Key words: Chlorpropamide, superdisintegrant and Immediate release tablet.