Published April 26, 2018 | Version v1
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Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System

Authors/Creators

  • 1. Servicio de Microbiología, Complejo Hospitalario Universitario A Coruña (CHUAC)-Instituto de Investigación Biomédica (INIBIC), A Coruña, Spain, Contributed equally.
  • 2. Unidad de Enfermedades Infecciosas y Microbiología Clínica, Hospital Universitario Virgen Macarena, Seville, Spain. Departamento de Microbiología. Universidad de Sevilla, Seville, Spain. Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain. Contributed equally.
  • 3. Servicio de Microbiología, Complejo Hospitalario Universitario A Coruña (CHUAC)-Instituto de Investigación Biomédica (INIBIC), A Coruña, Spain.
  • 4. Unidad de Enfermedades Infecciosas y Microbiología Clínica, Hospital Universitario Virgen Macarena, Seville, Spain.
  • 5. Unidad de Enfermedades Infecciosas y Microbiología Clínica, Hospital Universitario Virgen Macarena, Seville, Spain. Departamento de Microbiología. Universidad de Sevilla, Seville, Spain. Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain.

Description

The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.

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Journal article: 29463538/PMID (Handle)