Relevance of aquaporin-magnetic resonance imaging in the early recognition of Alzheimer's disease

The retrospective study includes patients with mild cognitive impairment (MCI) (60-85 years old, n=50), AD patients (60-85 years old, n=40) diagnosed in hospitals between January 2020 to January 2023, and age-matched normal control (NC) group of cognitively healthy individuals (n=40). All subjects underwent AQP-MRI examination to assess MRI grades. AQP-MRI voxel values of thalamus, substantia nigra, and pallidum, AQP apparent diffusion coefficients (AQP-ADC) and ADC values of regions of interest were recorded. Spearman's correlation was used to determine the correlation between AQP-ADC, ADC values and MCI, AD, ROC curve was used to judge the diagnostic value of AQP-ADC, AD values for MCI, AD.