PHYTOCHEMICAL & PHARMACOLOGICAL ACTIVITY OF DATURA METAL & CALENDULA OFFICINALIS

Analgesics from Natural Sources: There are various medicinal plants available in nature which are having analgesic activity. The medications most frequently involved were NSAIDs (30%), painkillers (15%, especially paracetamol, on its own or in association with a weak opiate), ENT medication (12%), benzodiazepines (7.5%) and digestive anti-acid preparations (7.5%). were noted in 9% of cases. In both model Hot Plate Method & Tail flick method we select 4 group Control, Standard, Datura Metal linn & Calendula officinalis (10% gel) and Datura Metal linn & Calendula officinalis (15% gel). In the Hot plate model comparative study show Datura Metal linn & Calendula officinalis (15% gel) show more effectiveness than Datura Metal linn & Calendula officinalis 10% gel after 15 minute of application while Datura Metal linn& Calendula officinalis 10% gel show most effective after 60 minute of application.

In the tail flick model the comparative study show Calendula officinalis (10% gel show more effective than Datura Metal linn 10% gel after 30 minute of application while Datura Metal linn (10% gel show most effective after 60 minute of application.