A Compressive Review on Solubility Enhancement Techniques

Solubility enhancement techniques aim to improve the dissolution and bioavailability of poorly water-soluble compounds. These methods encompass various approaches, including physical and chemical modifications, such as particle size reduction, amorphous solid dispersion, complexation, co-solvency, and lipid-based formulations. These techniques facilitate increased drug solubility and subsequent absorption, ultimately enhancing the therapeutic efficacy of pharmaceutical formulations. This review paper concludes various methods of solubility enhancement techniques used in pharmaceutical industries.