NEUTROPHILIC EXTRACELLULAR TRAPS (NETs) AS A CRITERION FOR ASSESSING THE EFFECTIVENESS OF THERAPY IN CHRONIC TONSILLITIS

The article evaluates the diagnostic possibilities of determining the level of NETs in the effectiveness of the treatment of chronic tonsillitis. A comparative study of neutrophils and netosis-transformed leukocytes was carried out in 120 patients diagnosed with chronic tonsillitis. %NETs were determined in blood smears of the "monolayer" type and smears from the surface of the palatine tonsil lacunae, which were then stained according to Romanovsky-Giemsa. Smear microscopy was performed using the MEKOS-C2 automated system. A comparative analysis of the number of identified NETs in groups showed that in patients with chronic tonsillitis, %NETs are 2 times higher than in healthy donors. Assessment of %NETs after the treatment showed that in the third group there was a decrease in this indicator in the blood by 40.5%, and in smears from the surface of the lacunae of the palatine tonsils by 33.3%. Thus, the combination of NM lacunae lavage and local NO-therapy procedures is the most effective way to influence the tissue focus of inflammation.