Published September 21, 2023
| Version v1
Journal article
Open
An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in pol g
Authors/Creators
- 1. Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biologyand Molecular Biophysics, University of Texas Medical Branch, Galveston Texas 77555
- 2. Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson Texas 75080
- 3. Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA
- 4. Department of Physics, Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson Texas 75080
- 5. Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biologyand Molecular Biophysics, Departmentof Pharmacology and Toxicology, University of TexasMedical Branch, Galveston, TX 77555, USA.
Description
Pol gamma is essential for mitochondrial genome integrity. Mutations to the polymerase causes disruption to it's various functions. Mutations in the 853 site causes various neurological issues. Structural and computational analysis of the wild-type and the mutants show that the mutation inhibits the process of opening and closing of the polymerase necessary for nucleotide incorporation. Furthermore, the dNTP does not form Watson-Crick base pairing with the templating residue, which is necessary for the reaction to take place.
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