Antibiotic-loaded implants for the management of osteomyelitis
Authors/Creators
- 1. Ortopedia y Traumatología, Hospital Pediátrico Baca Ortiz
- 2. Médico Postgradista de Ortopedia y Traumatología, Novaclínica Santa Cecília, Quito, Pontificia Universidad Católica del Ecuador.
- 3. Médico Postgradista de Ortopedia y Traumatología, Universidad de las Américas
- 4. Médico Postgradista de Ortopedia y Traumatología, Hospital Vozandes, Universidad de las Américas
- 5. Médico Postgradista de Ortopedia y Traumatología, Clínica Toa, Quito, Universidad de las Américas
- 6. Médico Postgradista de Ortopedia y Traumatología, Novaclínica, Quito, Universidad de las Américas
- 7. Médico General en funciones Hospitalarias, Hospital Pediátrico Baca Ortiz
Description
The management of osteomyelitis (OM) is quite challenging and diverse. The optimal therapeutic choice varies according to the duration of symptoms. Typically, acute OM involves antibiotic treatment, and chronic OM requires surgical procedures. Despite current advances in the understanding of OM and novel therapeutic options, this condition remains a significant health problem, non-resolution and recurrence being significantly frequent. To address this problem, new therapeutic approaches have been developed. For instance, antibiotic-loaded implants (ABLI) have been proposed as a novel approach in surgically-managed OM cases to decrease recurrence. A hefty amount of evidence supports the effectiveness and safety of ABLI. Current investigations are focused on establishing the best vehicles for local antibiotic therapy and antibiotic choice. This review aims to analyze available evidence regarding ABLI in the treatment of OM.