ROLE OF ASYMMETRIC DIMETHYLARGININE IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASES

The results of numerous studies in recent decades confirm the critical role of the vascular endothelium in the regulation of vascular homeostasis. A criterion for assessing the functional state of the endothelium is endothelium-dependent vasodilation, regulated by nitric oxide (NO). Despite clinical and experimental evidence of the relationship between increased plasma ADMA levels and the development of cardiovascular events, the clear etiopathogenetic role of ADMA in CVD requires further research. In order to accurately answer the question of whether ADMA is an etiological factor or a biological marker of CVD, additional analysis aimed at studying the biochemical, genetic and pharmacological aspects of ADMA metabolism is required, the results of which are presented in this article.