TOPIC: MONOGENIC DIABETES MELLITUS
Authors/Creators
- 1. Student, Department of General Medicine, Saveetha University, Chennai, Tamilnadu
- 2. Senior Lecturer, Department of General Medicine, Saveetha University, Chennai, Tamilnadu
Description
Aim: The main aim of the review is to describe about monogenic diabetes mellitus
Objective: Monogenic diabetes mellitus is more common in young people developing diabetes, it is important to be alert to the possibility of monogenic diabetes; hence we review about clinical features, genetics, prevalence, pathophysiology and treatment of monogenic diabetes mellitus.
Back Ground: Monogenic diabetes mellitus result from single gene mutation and account for 1-2% of cases in young people. The gene is mostly inherited from parents but may arise from spontaneous mutation. Most form of the monogenic diabetes is caused by a reduced ability to secrete insulin but rare variants result in insulin resistance.
Reason: The reason for this review is to provide broad Knowledgeof the genetic etiology of monogenic diabetes enables more appropriate treatment, better prediction of disease progression, screening of family members and genetic counselling.
Files
429.pdf
Additional details
References
- 1. Monogenic diabetes mellitus in Norway Oddmund Sovika, Henrik Underthun Irgensa, Janne Molnesa, Jorn V. Sagena , Lise Bjørkhauga , Helge Raedra, Anders Molveng, and Pål R. Njølstad 2. Monogenic form of diabetes: neonatal diabetes mellitus and maturity – onset diabetes of the young. 3. Monogenic forms of diabetes: neonatal diabetes mellitus and mody. 4. Monogenic diabetes byjulie 5. Diabetes- monogenic diabetes 6. Practical Aspects of Monogenic Diabetes: A Clinical Point of View by carl 7. Maternally inheriteddiabetes and deafness-diabetes de herencia 8. Maternally Inherited Diabetes and Deafness: A Multicenterstudy 9. Maternally inherited diabetes and deafness: a new diabetes subtype by Massey 10. Maternally inherited diabetes and deafness is a distinct subtype of diabetes and associates with a single point mutation in the mitochondrial tRNA Leu(UUR) by Johnson